Its a mathematical model presenting the interaction between a growing tumor and immune system. Model involves tumor cells, dendritic cell, helper Tcells, regulatory Tcells, effector cells and certain cytokines (e.g. TGFbeta, IL10, IL2 ) produced by these cells. It represent a dynamic regulation of tumor production/killing by different immune cells and cytokines. Model is derived from Tessi-Roberton 2012.

 Sheriff Rahuman sheriff@ebi.ac.uk EMBL-EBI Tiwari Krishna tiwarik@babraham.ac.uk Babraham Institute 2018-12-11T15:56:11Z 2018-12-11T15:56:11Z 2018-12-11T15:56:11Z sheriff@ebi.ac.uk Sheriff Rahuman EMBL-EBI tiwarik@babraham.ac.uk Tiwari Krishna Babraham Institute 2018-12-11T15:56:11 2020-07-09T13:59:00Z M Mr alpha5 k4 l_DC alpha5 Mr 1 k4 M l_DC 2020-07-09T13:59:00Z Mh lambda ul_DC lambda ul_DC 1 ul_DC Mh 2020-07-09T13:59:00Z I2 IL10 S4 TGFb pc sl_CD4_HTC pc sl_CD4_HTC 1 TGFb S4 1 IL10 I2 2020-07-09T13:59:00Z IL2 tc IL2 tc 2020-07-09T13:59:00Z Tx func_TRegs p1 p2 p1 func_TRegs p2 Tx 2020-07-09T13:59:00Z TGFb ts TGFb ts 2020-07-09T13:59:00Z Tx func_TRegs p3 p4 p3 func_TRegs p4 Tx 2020-07-09T13:59:00Z IL10 t1 IL10 t1 2020-07-09T13:59:00Z M Me alpha1 k4 l_DC alpha1 Me 1 k4 M l_DC 2020-07-09T13:59:00Z C1 IL2 S2 TGFb alpha2 sl_CD8_ETC alpha2 sl_CD8_ETC IL2 1 TGFb S2 C1 IL2 2020-07-09T13:59:00Z M Mh alpha3 k4 l_DC ul_DC alpha3 Mh 1 k4 M ul_DC l_DC 2020-07-09T13:59:00Z C1 IL2 S2 TGFb alpha4 sl_CD4_HTC alpha4 sl_CD4_HTC IL2 1 TGFb S2 C1 IL2 2020-07-09T13:59:00Z S3 TGFb alpha7 func_CD4_HTC alpha7 func_CD4_HTC TGFb S3 TGFb 2020-07-09T13:59:00Z C1 IL2 alpha6 sl_TRegs alpha6 sl_TRegs IL2 C1 IL2 2020-07-09T13:59:00Z P Tumorcells gamma gamma1 m Tumorcells 1 gamma1 P Tumorcells 1 m gamma P 1 P 2020-07-09T13:59:00Z S1 TGFb Tx func_CD8_ETC func_TRegs k2 k3 r0 r0 Tx 1 k2 Tx func_CD8_ETC 1 1 k3 func_TRegs func_CD8_ETC 1 TGFb S1 2020-07-09T13:59:00Z I1 IL10 R1 Tx alpha func_TRegs alpha Tx 1 IL10 I1 1 func_TRegs R1 
This compartment represent the microenvironment for tumor cells involving immune cells and cytokines produced from tumor/immune cells.
 2018-12-11T15:56:22Z 2018-12-11T16:00:20Z 2019-01-29T10:27:54Z 2018-12-11T16:19:17Z 2019-01-29T10:49:59Z 2019-01-29T10:28:00Z 2019-01-29T10:47:38Z 2019-01-29T10:37:46Z 2019-01-29T10:48:10Z 2019-01-29T10:48:05Z 
Concentration is in ng/ml
 2019-01-29T10:43:59Z 2019-01-29T10:43:20Z 2019-01-29T10:43:53Z 2019-01-29T10:48:02Z 2019-01-29T10:38:14Z 
Unit is number of Cells.
 2019-01-29T10:44:06Z 
Unit is number of Cells and its 0.3 of M
 2019-01-29T10:45:00Z 
Unit is number of Cells and its 0.6 of M
 2019-01-29T10:44:34Z 
Unit is number of Cells and its 0.1 of M
 2019-01-29T10:45:11Z 2018-12-11T17:00:38Z 2018-12-11T17:02:06Z 2018-12-11T17:02:31Z 2018-12-11T17:06:22Z 2018-12-11T17:06:52Z 2018-12-11T17:07:06Z 2018-12-11T17:07:15Z 2018-12-12T10:57:29Z 2018-12-12T10:58:11Z 2018-12-12T11:02:22Z 2018-12-12T11:02:49Z 2018-12-12T11:03:15Z 2018-12-12T11:03:58Z 2018-12-12T11:10:46Z 
Unit is number of cells
 2018-12-12T13:56:02Z 2018-12-13T14:08:19Z 2018-12-13T14:09:48Z 2018-12-13T14:11:29Z 2018-12-13T14:14:23Z 2018-12-13T14:29:02Z 2018-12-13T14:31:32Z 2018-12-13T14:31:51Z 2018-12-13T14:33:36Z 2018-12-13T14:33:52Z 2018-12-13T14:37:14Z 2018-12-13T14:37:32Z 2018-12-13T14:40:19Z 2018-12-13T14:40:54Z 
unit is ng/ml
 2018-12-13T14:41:10Z 2018-12-13T14:41:44Z 2018-12-13T14:42:36Z 
Unit id ng/ml/day/cell
 2018-12-13T15:34:28Z 
Unit id ng/ml/day/cell
 2018-12-13T15:34:45Z 
Unit id ng/ml/day/cell
 2018-12-13T15:35:02Z 
Unit is number of cells
 2018-12-13T14:38:04Z 2018-12-13T14:38:25Z 2018-12-13T14:39:16Z 2018-12-13T14:39:51Z 2018-12-13T14:40:07Z 
Unit id ng/ml/day/cell
 2018-12-13T15:35:36Z 
Unit id ng/ml/day/cell
 2018-12-13T15:35:50Z 2018-12-13T15:36:12Z 2018-12-13T15:36:35Z 2018-12-13T15:40:42Z 2018-12-13T15:41:00Z 2018-12-13T15:52:43Z 2019-01-02T10:51:08Z 2019-01-24T10:11:14Z Tumorcells gamma T1 m 1 Tumorcells 1 Tumorcells 1 n k1 P 1 P func_CD8_ETC func_TRegs func_TRegs_Production_from_CD4 func_TRegs_Production_from_CD4 func_TRegs_Production_from_sl_TRegs func_TRegs_Production_from_sl_TRegs func_TRegs_Production_from_CD4 func_TRegs_Production_from_sl_TRegs 2019-01-29T10:59:50Z MISC equation_for_Tumor_Growth_1 P Tumorcells gamma gamma1 m 2018-12-11T16:04:43Z MISC equation_for_Tumor_Kill_1 S1 TGFb Tx func_CD8_ETC func_TRegs k2 k3 r0 2019-01-29T11:02:38Z MISC equation_for_unlicensed_DC_production_1 I1 IL10 R1 Tx alpha func_TRegs 2019-01-29T10:54:58Z MISC equation_for_Dendritic_cell_licensing_1 Mh lambda ul_DC 2019-01-29T10:59:20Z MISC deltaA sl_TRegs 2019-01-29T10:58:44Z MISC equation_for_IL2_production_1 I2 IL10 S4 TGFb pc sl_CD4_HTC 2019-01-29T10:58:44Z MISC equation_for_IL2_Degradation_1 IL2 tc 2019-01-29T10:59:27Z MISC equation_for_TGF_beta_Production_1 Tx func_TRegs p1 p2 2019-01-29T10:59:26Z MISC equation_for_TGF_beta_Degradation_1 TGFb ts 2019-01-29T10:58:42Z MISC equation_for_IL10_production_1 Tx func_TRegs p3 p4 2019-01-29T10:58:41Z MISC equation_for_IL10_degradation_1 IL10 t1 2019-01-29T11:00:37Z MISC deltaU ul_DC 2019-01-29T10:58:45Z MISC deltaD l_DC 
ETC= Effector T cells
 2019-01-29T10:59:15Z MISC equation_for_short_lived_CD8_production_1 M Me alpha1 k4 l_DC 2019-01-29T10:59:14Z MISC deltaA sl_CD8_ETC 2019-01-29T10:55:45Z MISC equation_for_fully_functional_CD8_production_1 C1 IL2 S2 TGFb alpha2 sl_CD8_ETC 2019-01-29T10:55:44Z MISC deltaE func_CD8_ETC 2019-01-29T10:59:09Z MISC equation_for_short_lived_CD4_HTC_production_1 M Mh alpha3 k4 l_DC ul_DC 2019-01-29T10:59:08Z MISC deltaA sl_CD4_HTC 2019-01-29T10:54:59Z MISC equation_for_fully_functional_CD4_HTC_1 C1 IL2 S2 TGFb alpha4 sl_CD4_HTC 2019-01-29T10:59:23Z MISC equation_for_short_lived_TReg_production_1 M Mr alpha5 k4 l_DC 2019-01-29T10:58:30Z MISC equation_for_fully_functional_TRegs_production_by_CD4_HTC_1 S3 TGFb alpha7 func_CD4_HTC 2019-01-29T10:55:26Z MISC deltaH func_CD4_HTC 2019-01-29T10:58:22Z MISC deltaR func_TRegs 2019-01-29T10:58:32Z MISC equation_for_fully_functional_TRegs_production_by_sl_TRegs_1 C1 IL2 alpha6 sl_TRegs